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| Thread ID: 114477 | 2010-12-04 17:23:00 | Our token American | tut (12033) | PC World Chat |
| Post ID | Timestamp | Content | User | ||
| 1158790 | 2010-12-08 07:14:00 | I would avoid taking grapefruit juice with ANY medications. Grapefruit juice and morphine is definitely a no-no. |
Renmoo (66) | ||
| 1158791 | 2010-12-08 07:26:00 | I'm just off to have a couple of Brompton Cocktails. :) | Snorkbox (15764) | ||
| 1158792 | 2010-12-08 10:45:00 | Good to see ya Joe. Meat and fruit should not be had together. |
rob_on_guitar (4196) | ||
| 1158793 | 2010-12-09 06:52:00 | English version: Enzymes are proteins that breakdown substances into small molecules, which are then eliminated from the body . There is one particular group of enzymes called Cytochrome P450, which are responsible for breaking down the majority group of medications available in the market . Grapefruit juice contains an ingredient which can stop the Cytochrome P450 enzymes from metabolising the drugs . As a result, if Joe takes amitriptyline and washes it down with a cup of grapefruit juice, the enzyme's activities would come to a halt, allowing the amitriptyline level in the blood to slowly build up, causing toxicity eventually . As I understand it, most drugs are prescribed with the knowledge that the liver will cut it's efficacy in a certain percentage the first time venal blood with the drug passes through it . If the metabolizing of the drug to less-toxic levels (as seen by the liver) isn't accomplished - and therefor the 'first pass' removal and rendering of the drug to lower percentages isn't viable, then the drug can rise above normal dosages to potentially fatal levels . Right? . . . Does any renal activity account for this 'rendering-safe' too? And another question - is there any difference in administration of the drug (IM v PO) if grapefruit is consummed? Good to see ya Joe . Meat and fruit should not be had together . Unless the 'fruit' is a fine wine . BTW: It's nice to be seen too - thanks . |
SurferJoe46 (51) | ||
| 1158794 | 2010-12-09 07:47:00 | Just be thankful SJ you aren't on those other pills where it is dangerous to eat chocolate or broad beans (I think non English speakers like Americans call them fava beans, or some other barbaric name like 'gallons'), or drink red wine! By contrast, it isn't any great loss not to drink grapefruit juice . . . |
John H (8) | ||
| 1158795 | 2010-12-09 08:49:00 | As I understand it, most drugs are prescribed with the knowledge that the liver will cut it's efficacy in a certain percentage the first time venal blood with the drug passes through it . Yup, agreed . If the metabolizing of the drug to less-toxic levels (as seen by the liver) isn't accomplished - and therefor the 'first pass' removal and rendering of the drug to lower percentages isn't viable, then the drug can rise above normal dosages to potentially fatal levels . Right? . . . Does any renal activity account for this 'rendering-safe' too? 1) Metabolism of drug doesn't happen solely in the liver . A variety of other enzymes exist in the bloodstream and other organs too . 2) Metabolism doesn't always mean the drug is turned into something less toxic . A classical case is paracetamol, whereby it can be metabolised into something sinister (NAPQI) which has the potential of causing liver failure . 3) Sometimes having metabolism is a good thing . For instance, when codeine is metabolised by CYP2D6 isoenzymes, the byproduct is morphine, which allows painkiller effect to be manifested in the body . 4) Kidney has a certain degree of metabolism capability as well . And another question - is there any difference in administration of the drug (IM v PO) if grapefruit is consummed? What sort of difference are we talking about? |
Renmoo (66) | ||
| 1158796 | 2010-12-09 08:51:00 | Sorry, but I am too tired after a long day at work today. I know what you meant by the last question, but I will let you elaborate more on it first before answering it. | Renmoo (66) | ||
| 1158797 | 2010-12-10 08:37:00 | OK - if you have the drug administered as an intra-muscular inoculation verses by mouth and therefor through the digestive system and into the blood, there must be a difference in the 'first-pass' scene between the two - right? | SurferJoe46 (51) | ||
| 1158798 | 2010-12-11 22:53:00 | intra-muscular inoculation verses by mouth This must be a new procedure yet to reach our shores? :p |
WalOne (4202) | ||
| 1158799 | 2010-12-11 23:53:00 | This must be a new procedure yet to reach our shores? :p Danged spellcheckers! I know youse guys like lots of extra 'u's in things and I never doubted it's information at all . OK - can we TALK about this, poetically eg: verses? But don't cha gotta open your mouth to take a pill? Suppositories are so ---- so, er --- you know! |
SurferJoe46 (51) | ||
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